Table 1.

Deregulated Clock Genes in Cancers

Type of Cancer	Deregulated Clock Genes	References
Breast Cancer	Bmal1, Clock, Tim, Cry1, Per1, Cry2, Per2, Per3, Npas2	[39, 40, 46, 48, 55–57]
Colorectal Cancer	Per1, Per2, Per3, Clock, Npas2, Tim	[58–64]
Colon Cancer	Per2	[9, 65]
Diffuse large B-cell Lymphoma	Clock, Bmal1	[66]
Endometrial Cancer	Per1, Per2, Per3, Cry1	[45, 67, 68]
Esophageal Cancer	Dec1, Dec2, Per, Cry	[69]
Glioma	Cry1, Per1, Per2, Per3, Cry2,	[70–72]
Gastric Cancer	Cry1 Per2	[73]
HNSCC (Head and Neck Squamous Cell Carcinoma)	Cry1, Per1, CKIε, Per2, Per3, Bmal1, Cry2, Bmal1, Tim	[74–77]
Hepatocellular Carcinoma	Cry2, Per1, Per3, Per2, Tim	[78, 79]
Leukemia (Acute Lymphocytic Leukemia; Chronic Lymphocytic Leukemia, & Chronic Myeloid Leukemia)	Per3, Cry2, Clock, Per1, Cry1, CKIε, Per2, Bmal1	[74, 80–83]
Lung Cancer	Per1, Per2, Per3, Clock	[60, 84–87]
Malignant Pleural Mesothelioma	Per1, Per3, Npas2, Bmal1, Cry2, Rev-erbα, Rev-erbβ, Tim	[88–90]
Non-Hodgkin’s Lymphoma	Cry2, Npas2, Bmal1	[70, 91, 92]
Osteosarcoma	Per2, CK1ε	[88, 93]
Ovarian Cancer	Clock, Bmal1, Cry2, Cry1, Per2, Per3, Per1, CK1ε.	[94–96]
Pancreatic Cancer	Per2, Bmal1, Cry1, Cry2, Per1, Per3, CK1ε, Clock, Dec1, Tim	[56, 97–99]
Prostate Cancer	Cry1, Bmal1, Cry2, Clock, Per2, Per1, Per3, Npas2, CK1ε,	[100, 101]