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. 2022 Feb 4;13(2):118. doi: 10.1038/s41419-022-04576-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Different staining level for PGK1 protein was shown in a paired noncancerous/tumor tissue from a commercial tissue microarray. Red arrows indicated positive staining for PGK1. B Cell endogenous PGK1 was mainly located in cytoplasm by cell fluorescence analysis. Red arrows meant positive fluorescent staining. C PGK1 level was increased in KIRC tissues by quantitative analysis of 90 cases of NATs and KIRC tissues. D The serum PGK1 was increased in KIRC patients compared to healthy persons by Western blot detection. Reversible Ponceau staining was used as a total loading control. E Associations of PGK1 levels and pathologic variables including grade, stage, tumor size, gender, and age obtained from tissue microarray. PGK1 protein level is well correlated with tumor size and tumor stage of KIRC (P < 0.05). F Kaplan–Meier overall survival curves for KIRC patients based on PGK1 expression from tissue microarray results. G Heatmap (top chart) and boxplot (bottom chart) for the transcriptional profiling of PGK1 in KIRC tissues (n = 530) and NATs (n = 72) respectively, derived from TCGA-KIRC species. H KIRC patients with high PGK1 mRNA level showed a shorter relapse-free survival (P < 0.05) from the KM-plotter database analysis.