Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 4;13(2):118. doi: 10.1038/s41419-022-04576-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — PGK1 improved cell proliferation (A), clonogenic capacity (B) and migration (C) in 786-O and ACHN cells. Data were presented as the mean ± SD. D The epithelial-mesenchymal transition (EMT) marker proteins were detected in the PGK1-overexpressing RCC cells. E PGK1 overexpression enhanced tumor growth of xenograft mice. Upper panel: tumor growth curve of xenograft mice during inoculation period. 786-O cells stably overexpressing PGK1 or control plasmid were injected subcutaneously into BALB/c nude mice (n = 4), and tumor sizes and morphology were evaluated 5 times after injection. * P < 0.05. Bottom panel: Representative images of xenograft tumors at day 22 after subcutaneous cell injection. F Comparison of Ki-67 staining between 786-O^-PGK1 and 786-O^-NC cells. G, H Knockdown of PGK1 expression inhibited the cell clonogenic capacity in vitro and the tumorigenicity of 786-O cells in nude mice.