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. 2021 Aug 31;29(2):381–392. doi: 10.1038/s41418-021-00862-4

Fig. 4. FBXW2 decreases transcriptional activity of p65.

Fig. 4

A The volcano map results of knocking down FBXW2 in MCF-7 cells. B Heat map representing the most significantly regulated genes detected in RNA-seq analysis with knockdown of FBXW2 in MCF-7 cells. C Gene set enrichment analysis (GSEA) of regulated genes in FBXW2 knockdown MCF-7 cells. D, E Examination of the mRNA levels of LIN28B, QPCT, SCN5A, and WT1 by RT-PCR analyses in breast cancer cells. F, G Luciferase reporter assays were performed in FBXW2 knockdown breast cancer cells. H, I CHIP assays were performed using FBXW2 knockdown breast cancer cells. The results were normalized against the values of IgG controls. (All data represent mean ± SEM n = 3), *p < 0.05.