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. 2021 Aug 31;29(2):381–392. doi: 10.1038/s41418-021-00862-4

Fig. 5. The FBXW2–p65 axis regulates breast cancer stemness via upregulation of SOX2.

Fig. 5

A, B SOX2 mRNA levels were quantitated by RT-PCR in FBXW2-depleted breast cancer cells rescued with rFBXW2. C, D Immunofluorescence analysis of FBXW2-depleted breast cancer cells rescued with rFBXW2. E Tumor sphere formation assays were performed in FBXW2-depleted breast cancer cells rescued with rFBXW2. F, G Breast cancer cells were overexpressed Flag-tagged FBXW2 with shRNA-control or shRNA-p65 lentiviral. (All data represent mean ± SEM n = 3), *p < 0.05.