Table 2.
Comparison of laboratory results among multi-system inflammatory syndrome in children cohort stratified by presence of cardiac complications.
| Variable of interest | All cases (n = 39) | Cardiac complications present (n = 19) | Cardiac complications absent (n = 20) | p-value |
|---|---|---|---|---|
| Medians and IQR | Medians and IQR | Medians and IQR | ||
| SARS-CoV-2 (% PCR positive) (n (%)) | 20 (51%) | 9 (47%) | 11 (55%) | 0.75 |
| SARS-CoV-2 (% antibody positive) (n (%)) | 36 (97%) (n = 37) | 17 (100%) (n = 17) | 19 (95%) | 0.54 |
| Creatinine - initial (mg/dl) | 0.49 (0.40–0.77) | 0.59 (0.42–1.20) | 0.48 (0.39–0.55) | 0.15 |
| Creatinine - max (mg/dl) | 0.54 (0.43–0.83) | 0.63 (0.43–1.20) | 0.52 (0.44–0.64) | 0.13 |
| BUN - initial (mg/dl) | 11 (8–15) | 13 (8–21) | 9.5 (7.5–11.5) | 0.09 |
| BUN - max (mg/dl) | 17 (14–22) | 19 (15–25) | 15.5 (13–18.5) | 0.09 |
| CRP - initial (mg/dl) | 14.15 (10.37–18.73) | 13.4 (8.99–19.12) | 14.92 (11.49–17.60) | 0.76 |
| CRP - max (mg/dl) | 17.29 (12.52–22.20) | 16.85 (11.40–23.02) | 17.60 (14.90–21.65) | 0.63 |
| LDH - initial (unit/L) | 287.5 (234–349) (n = 38) | 292 (256–349) (n = 18) | 287.5 (228–342) | 0.54 |
| LDH - max (unit/L) | 362.5 (310–491) (n = 38) | 383 (331–636) (n = 18) | 343 (304–459.5) | 0.18 |
| Ferritin - initial (ng/L) | 314.5 (242–566) (n = 38) | 432 (249–598) (n = 18) | 313.5 (225.5–496.5) | 0.29 |
| Ferritin - max (ng/L) | 528 (340–855) (n = 38) | 688 (414–937) (n = 18) | 407.5 (321.5–618.5) | 0.07 |
| Fibrinogen - initial (mg/dl) | 495 (397–601) | 511 (426–565) | 476.5 (396.0–622.5) | 0.75 |
| Fibrinogen - max (mg/dl) | 518 (426–645) | 551 (485–683) | 477 (403.0–622.5) | 0.12 |
| Hemoglobin - initial (gm/dl) | 11.5 (10.3–12.6) | 11.8 (10.4–13.3) | 11.2 (10.15–12.1) | 0.17 |
| Hemoglobin - min (gm/dl) | 8.4 (7.3–9.2) | 8.4 (7.2–9.2) | 8.3 (7.4–9.15) | 0.99 |
| WBC - initial (K/mcl) | 9.08 (5.88–15.34) | 11.32 (9.08–17.59) | 7.225 (5.34–8.81) | 0.01 |
| WBC - min (K/mcl) | 4.74 (4.16–5.58) | 4.7 (4.43–5.55) | 4.9 (3.565–5.615) | 0.79 |
| WBC - max (K/mcl) | 15.34 (10.57–20.75) | 16.78 (11.47–23.95) | 13.07 (9.525–18.065) | 0.17 |
| Manual lymphocyte - initial (K/mcl) | 11 (4–23) (n = 35) | 11 (3–19) (n = 18) | 13 (8–25) (n = 17) | 0.24 |
| Manual lymphocyte - min (K/mcl) | 8 (3–13) (n = 35) | 4(3–13) (n = 18) | 10 (8–13) (n = 17) | 0.05 |
| Manual Lymphocyte - max (K/mcl) | 48 (36–69) (n = 35) | 48.5 (36–62) (n = 18) | 47 (37–69) (n = 17) | 0.83 |
| Segmented neutrophil - initial (K/mcl) | 71 (59–79) (n = 35) | 74.5 (68–80) (n = 18) | 63 (38–71) (n = 17) | 0.02 |
| Segmented neutrophil - min (K/mcl) | 34 (18–52) (n = 35) | 35 (24–44) (n = 18) | 34 (17–52) (n = 17) | 0.29 |
| Segmented neutrophil - max (K/mcl) | 80 (71–87) (n = 35) | 83 (72–89) (n = 18) | 76 (64–82) (n = 17) | 0.17 |
| Eosinophil - initial (K/mcl) | 2 (1–3) (n = 34) | 2 (1–3) (n = 18) | 2 (1–3) (n = 16) | 0.89 |
| Eosinophil - max (K/mcl) | 4 (3–8) (n = 34) | 4 (3.0–8.0) (n = 18) | 3.5 (2.5–8.0) (n = 16) | 0.94 |
| Platelet count - initial (K/mcl) | 162 (126–236) | 164 (151–272) | 153 (102–234) | 0.23 |
| Platelet count - min (K/mcl) | 147 (99–187) | 151 (127–187) | 127.5 (76–183) | 0.19 |
| Platelet count - max (K/mcl) | 612 (509–700) | 547 (495–698) | 616 (521.5–710) | 0.55 |
| ALT - initial (unit/L) | 29 (17–53) | 25 (17–43) | 37 (18–74) | 0.27 |
| ALT - max (unit/L) | 46 (28–77) | 46 (27–69) | 48 (31–106) | 0.87 |
| AST - initial (unit/L) | 39 (21–60) | 37 (27–57) | 42.5 (17–74) | 0.88 |
| AST - max (unit/L) | 60 (43–102) | 60 (43–105) | 60 (44.5–84.5) | 0.86 |
| PTT activated - initial (second) | 35.75 (33.5–40.2) (n = 38) | 35.75 (33.6–38.5) (n = 18) | 36.75 (33.1–42.2) | 0.49 |
| PTT activated - max (second) | 44.3 (38.9–48.3) (n = 38) | 44.35 (38.7–51.9) (n = 18) | 44.2 (39.35–47.75) | 0.98 |
| Prothrombin time - initial (second) | 15.65 (14.7–17) (n = 38) | 15.95 (15–16.6) (n = 18) | 15.65 (14.3–17.05) (n = 20) | 0.619 |
| Prothrombin time - max (second) | 17 (15.8–18.1) (n = 38) | 17 (15.8–20) (n = 18) | 16.95 (15.8–17.95) (n = 20) | 0.629 |
| Prothrombin time INR - initial | 1.235 (1.14–1.37) (n = 38) | 1.265 (1.18–1.33) (n = 18) | 1.235 (1.11–1.375) | 0.61 |
| Prothrombin time INR - max | 1.37 (1.25–1.48) (n = 38) | 1.37 (1.25–1.67) (n = 18) | 1.365 (1.25–1.46) | 0.63 |
| N-terminal B-type natriuretic peptide - initial (pg/ml) | 1695 (627–4498) (n = 38) | 2292.5 (598–4814) (n = 18) | 1692.5 (788–3565) | 0.99 |
| N-terminal B-type natriuretic peptide - max (pg/ml) | 9347 (2426–17,886) (n = 38) | 14,396 (8814–20,158) (n = 18) | 3205.5 (1466–10,624.5) | 0.01 |
| Troponin I - initial (ng/ml) | 0.08 (0.04–0.13) (n = 33) | 0.06 (0.04–0.19) (n = 17) | 0.085 (0.035–0.12) (n = 16) | 0.75 |
| Troponin I - max (ng/ml) | 0.16 (0.09–0.66) (n = 33) | 0.27 (0.1–1.04) (n = 17) | 0.145 (0.09–0.435) (n = 16) | 0.41 |
| D-Dimer - initial (ug/ml) | 3.17 (1.97–5.72) | 3.45 (1.99–5.96) | 3.00 (1.93–4.39) | 0.39 |
| D-Dimer - max (ug/ml) | 4.02 (3.10–7.12) | 4.88 (3.10–7.79) | 4.01 (2.89–6.66) | 0.69 |
ALT = alanine aminotransferase; AST = aspartate aminotransferase; BUN = blood urea nitrogen; CRP = C-reactive protein; INR = international normalised ratio; IQR = interquartile range; LDH = lactate dehydrogenase; Max = maximal; Min = minimal; PCR = polymerase chain reaction; PTT = partial thromboplastin time; SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2; WBC = white blood cells.
Statistically significant differences are marked by bold rows.