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. 2022 Feb 4;12:1919. doi: 10.1038/s41598-022-05179-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Experimental protocol and timeline. Lamotrigine, Levetiracetam and placebo were administered on separate occasions in experiment 1 and XEN1101 and placebo on separate occasions in experiment 2. Both studies followed a randomized and crossover design. RMT, Resting-state EEG and TMS-EEG sessions were recorded for each subject at baseline (pre-drug measurement) and at 2 (experiment 1 and 2), 4 and 6 h (experiment 2) after drug intake. Five minutes before each post-drug measurement a blood sample was taken to measure drug plasma concentration.