TABLE 3.
Frequencies of combined de novo metastases
| Variable | Male BC (n = 1704) | Female BC (n = 225,417) | p values | ||
|---|---|---|---|---|---|
| Number | (%) | Number | (%) | ||
| One site | |||||
| Bone‐only | 41 | 2.41 | 3931 | 1.74 | 0.038 |
| Brain‐only | 1 | 0.06 | 136 | 0.06 | 0.725 |
| Liver‐only | 0 | 0 | 718 | 0.32 | 0.008 |
| Lung‐only | 12 | 0.7 | 1022 | 0.45 | 0.125 |
| DL‐only | 0 | 0 | 117 | 0.05 | 1 |
| Other‐only | 0 | 0 | 52 | 0.02 | 1 |
| Two sites | |||||
| Bone brain | 2 | 0.12 | 174 | 0.08 | 0.381 |
| Bone liver | 6 | 0.35 | 794 | 0.35 | 1 |
| Bone lung | 27 | 1.58 | 907 | 0.4 | 0 |
| Bone DL | 1 | 0.06 | 62 | 0.03 | 0.374 |
| Bone other | 1 | 0.06 | 40 | 0.02 | 0.266 |
| Brain liver | 0 | 0 | 19 | 0.01 | 1 |
| Brain lung | 0 | 0 | 51 | 0.02 | 1 |
| Brain DL | 0 | 0 | 0 | 0 | 1 |
| Brain other | 0 | 0 | 1 | 0 | 1 |
| Liver lung | 0 | 0 | 238 | 0.11 | 0.432 |
| Liver DL | 0 | 0 | 13 | 0.01 | 1 |
| Liver other | 0 | 0 | 4 | 0 | 1 |
| Lung DL | 0 | 0 | 25 | 0.01 | 1 |
| Lung other | 1 | 0.06 | 7 | 0 | 0.058 |
| DL other | 0 | 0 | 16 | 0.01 | 1 |
| Three sites | |||||
| Bone brain liver | 0 | 0 | 66 | 0.03 | 1 |
| Bone brain lung | 1 | 0.06 | 99 | 0.04 | 0.529 |
| Bone brain DL | 0 | 0 | 3 | 0 | 1 |
| Bone brain other | 0 | 0 | 1 | 0 | 1 |
| Bone liver lung | 5 | 0.29 | 447 | 0.2 | 0.4 |
| Bone liver DL | 0 | 0 | 28 | 0.01 | 1 |
| Bone liver other | 0 | 0 | 16 | 0.01 | 1 |
| Bone lung DL | 0 | 0 | 38 | 0.02 | 1 |
| Bone lung other | 1 | 0.06 | 8 | 0 | 1 |
| Bone DL other | 0 | 0 | 20 | 0.01 | 1 |
| Brain liver lung | 0 | 0 | 21 | 0.01 | 1 |
| Brain liver DL | 0 | 0 | 2 | 0 | 1 |
| Brain liver other | 0 | 0 | 0 | 0 | 1 |
| Brain lung DL | 0 | 0 | 2 | 0 | 1 |
| Brain lung other | 0 | 0 | 1 | 0 | 1 |
| Brain DL other | 0 | 0 | 2 | 0 | 1 |
| Liver lung DL | 1 | 0.06 | 5 | 0 | 0.044 |
| Liver lung other | 0 | 0 | 2 | 0 | 1 |
| Liver DL other | 0 | 0 | 4 | 0 | 1 |
| Lung DL other | 0 | 0 | 9 | 0 | 1 |
| Four sites | |||||
| Bone brain liver lung | 1 | 0.06 | 99 | 0.04 | 0.529 |
| Bone brain liver DL | 0 | 0 | 1 | 0 | 1 |
| Bone brain liver other | 0 | 0 | 0 | 0 | 1 |
| Bone brain lung DL | 0 | 0 | 3 | 0 | 1 |
| Bone brain lung other | 0 | 0 | 1 | 0 | 1 |
| Bone brain DL other | 0 | 0 | 0 | 0 | 1 |
| Bone liver lung DL | 0 | 0 | 13 | 0.01 | 1 |
| Bone liver lung other | 0 | 0 | 4 | 0 | 1 |
| Bone liver DL other | 0 | 0 | 7 | 0 | 1 |
| Bone lung DL other | 1 | 0.06 | 16 | 0.01 | 0.12 |
| Brain liver lung DL | 0 | 0 | 0 | 0 | 1 |
| Brain liver lung other | 0 | 0 | 2 | 0 | 1 |
| Brain liver DL other | 0 | 0 | 1 | 0 | 1 |
| Brain lung DL other | 0 | 0 | 1 | 0 | 1 |
| Liver lung DL other | 0 | 0 | 2 | 0 | 1 |
| Five sites | |||||
| Bone brain liver lung DL | 0 | 0 | 7 | 0 | 1 |
| Bone brain liver lung other | 0 | 0 | 4 | 0 | 1 |
| Bone brain liver DL other | 0 | 0 | 2 | 0 | 1 |
| Bone brain lung DL other | 0 | 0 | 3 | 0 | 1 |
| Bone liver lung DL other | 0 | 0 | 8 | 0 | 1 |
| Brain liver lung DL other | 0 | 0 | 1 | 0 | 1 |