FIGURE 5.

Effect of the GSMs AZ4800, AZ4126 and E2012 on Aβ‐like peptide production. Representative MALDI‐TOF MS spectrum of secreted Aβ‐like peptides using α‐FLAG–immunoprecipitated conditioned medium from HEK293 cells stably expressing (A) FLAG‐CadΔE, (B) FLAG‐B2ΔE and (C) FLAG‐A4ΔE treated with DMSO (control), L685,458, AZ4800, AZ4126 and E2012. Each peak of the Aβ‐like peptide from all substrates is plotted as a percentage of DMSO. The bars represent the means of four to five experiments (N = 4–5) in duplicates (n = 2) with error bars indicating SEM. The level of significance was set at p ≤ 0.05 for *, p ≤ 0.005 for ** and p ≤ 0.001 for ***