FIGURE 2.

Protective effect of uridine on CCl4‐induced liver damage. (A) Sirius Red staining showed that collagen deposition significantly decreased by uridine treatment. Mice were treated with CCl4, CCl4+uridine or oil as described in materials and methods sections. Data are expressed as the means ± standard deviation. *p < 0.05 (t‐test, n = 6). (B) Masson staining showed that uridine therapy could attenuate liver fibrosis. Mice were treated with CCl4, CCl4+uridine or oil as described in materials and methods sections. (C) Expression level of the collagen type‐I mRNA was down‐regulated after uridine treatment. Data are expressed as the means ± standard deviation. *p < 0.05 (t‐test, n = 6). Asterisks indicate significant differences between means (p < 0.05)