FIGURE 6.

Uridine relieved CCl4‐induced cytotoxicity in the hepatocyte line. (A) uridine inhibited CCl4‐induced apoptosis of liver cells. The apoptosis model was established by 24 h treatment with CCl4 (10 mmol/L). The cells were pre‐treated with uridine (0.2–0.4 mg/mL) for 10 h before CCl4 stimulation. (B) The results from mitochondrial membrane potential analysis indicated that the cell apoptosis rate was down‐regulated by uridine pre‐treatment. (C) Flow cytometry analysis showed that uridine restored the ratio of S phase cells. (D) Effect of uridine on the expression level of Bcl‐2 and Bax and Cleavaged caspase‐3. Asterisks indicate significant differences between means (p < 0.05)