FIGURE 9.

Effect of uridine on activated hepatic stellate cell (HSC). (A) Uridine down‐regulated the expression of α‐SMA in the activated HSCs. An activated cell model of HSC was established by stimulating it with the TGF‐β (25 ng/ml) for 24 h. The cells were pre‐treated with uridine for 10 h before TGF‐β stimulation. (B) Effect of uridine down‐regulated the expression of Collagen type‐I (ColI) and fibronectin (Fn). (C) Uridine inhibited the migration of the activated HSC. Asterisks indicate significant differences between means (p < 0.05)