TABLE 3.

Mixed effects regression estimates of the relationships between apathy group, baseline CDR, and functional decline over time

Variables	Coeff.	Std. Err.	P	[95% conf. interval]
Overall rate of worsening over time (by visit)	1.870	(0.035)	<.001	[1.801,1.939]
Apathy group (reference: never apathetic in any visit)
Intermittent apathy	0.399	(0.220)	.070	[‐0.032,0.830]
Persistent apathy	1.467	(0.202)	<.001	[1.070,1.863]
Always apathy	2.519	(0.253)	<.001	[2.023,3.015]
Relationship between apathy group and rate of decline over time (interactions with time)
Intermittent apathy	0.849	(0.050)	<.001	[0.751,0.948]
Persistent apathy	1.253	(0.051)	<.001	[1.154,1.353]
Always apathy	1.264	(0.071)	<.001	[1.125,1.404]
Baseline CDR (reference: CDR = 0.5)
CDR = 1	10.500	(0.179)	<.001	[10.149,10.851]
CDR ≥ 2	19.458	(0.308)	<.001	[18.855,20.062]
Relationship between baseline CDR and rate of decline over time (interactions with time)
CDR = 1	‐0.321	(0.045)	<.001	[‐0.409,‐0.233]
CDR ≥ 2	‐1.746	(0.085)	<.001	[‐1.913,‐1.579]

Notes: Model controlled for age, male, race/ethnic groups, education, indicator for living alone, years of follow up, any APOE ε4 genotype, indicator for missing APOE values, indicators for hypertension, hypercholesterolemia, diabetes, number of medications, Geriatric Depression Scale (GDS), and indicators for ADC sites. Full results and interpretations are included in supporting information.

Abbreviation: APOE, apolipoprotein E; CDR, Clinical Dementia Rating.