FIGURE 5.

Alterations of ZFHX3 in human PCa and their potential impacts. (A) Distribution of ZFHX3 copy number variations (CNVs) in human PCa specimens with different Gleason scores. (B) Deletion of ZFHX3 at one or two copies correlates with AR activity scores defined by a panel of 27 genes. (C) ZFHX3 mRNA expression level, as defined by the Z‐score of log₂(RSEM normalized count +1) relative to all PCa samples, is reduced in PCa; and the reduction is more frequent in PCa with higher Gleason scores. (D) Downregulation of ZFHX3 in PCa correlates with worse disease‐free survival in PCa patients, as determined by the Kaplan‐Meier analysis. (E) Enrichment of hallmark gene sets in ZFHX3‐high and ZFHX3‐low PCa specimens, with the x‐axis representing normalized enrichment scores (NES). HR, hazard ratio; ns, not significant; **, p < 0.01; ***, p < 0.001