Fig. 3.

Brain drug delivery algorithm. It is mainly divided into three components made of interstitial, chemical modification, and novel delivery methods. Each of these components is subdivided into different categories (green color) and methods (orange color). The novel delivery component consists of 4 categories which include polymeric, peptide, and lipid carriers as well as gene therapy technique. Meanwhile, the polymeric carrier system involves the use of nanospheres, nanoparticles, and nanoconjugates, the lipid carrier system consists of liposomes, solid lipids, and viral/peptide vectors delivery systems