TABLE 1.
Alignment of direct repeats that flank the MSP variable regionsa
| MSP copy | Amino acid sequence
|
|||
|---|---|---|---|---|
| LLAK DR1 | LAKT DR1 | LLAK DR2 | LAKT DR2 | |
| HGE-1 VAR1 | CTA CTA GCT AAG | TTA CTT GCT AAA | ||
| HGE-3 VAR1 | CTA CTA GCT AAG | TTA CTA GCT AAG | ||
| HGE-6 VAR1 | CTA CTA GCT AAG | TTA CTA GCT AGA | ||
| HGE-7 VAR1 | NAb | TTA CTA GCT AAA | ||
| HGE-7 VAR2 | CTA CTA GCT AAG | TTA CTA GCT AAA | ||
| HGE-8 VAR1 | CTA CTA GCT AAG | NA | ||
| HGE-12 VAR1 | CTA CTA GCT AAG | NA | ||
| HGE-23 VAR1 | CTA CTA GCT AAG | CTA CTA GCT AAA | ||
| HGE-23 VAR2 | CTA CTA GCT AAG | TTA CTA GCT AAA | ||
| HGE-23 VAR3 | CTA CTA GCT AAG | NA | ||
| HGE-24 VAR1 | CTA CTG GCT AAG | TTA CTA GCT AAA | ||
| Consensus | CTA CTA GCT AAG | TTA CTA GCT AAA | ||
| HGE-1 VAR1 | CTT GCC AAA ACC | CTT GCT AAA ATT | ||
| HGE-3 VAR1 | CTT GCT AAG ACC | CTA GCT AAG ACT | ||
| HGE-6 VAR1 | CTT GCC AAG ACT | CTA GCT AGA ACT | ||
| HGE-7 VAR1 | NA | CTA GCT AAA ACT | ||
| HGE-7 VAR2 | CTT GCC AAG ACC | CTA GCT AAA ACT | ||
| HGE-8 VAR1 | NA | NA | ||
| HGE-12 VAR1 | CTT GCT AAA ACC | NA | ||
| HGE-23 VAR1 | CTT GCC AAA ACC | CTA GCT AAA ACT | ||
| HGE-23 VAR2 | CTT GCC AAA ACC | CTA GCT AAA ACT | ||
| HGE-23 VAR3 | CTT GCC AAA ACT | NA | ||
| HGE-24 VAR1 | CTT GCT AAG ACC | CTA GCT AAA ACT | ||
| Consensus | CTT GCC AAA ACC | CTA GCT AAA ACT | ||
a
The MSP copy number and the amino acid sequences of direct repeats 1 (DR1) and 2 (DR2) as well as the respective nucleotide sequence alignments and consensus sequences are shown. The direct repeats for LLAK and LAKT are indicated in Fig. 2 by large and small arrowheads, respectively. The MSP copy number includes the clone name (HGE-N) and the associated variable region (VARn), as shown in Fig. 2.
b
NA, the sequence was not available for evaluation.