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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Neuropharmacology. 2021 Dec 15;205:108925. doi: 10.1016/j.neuropharm.2021.108925

Fig. 3. Escalating dose forced choice oxycodone prior to oxycodone TBC-DID does not lead to oxycodone bottle preference.

Fig. 3.

A) The schematic shows the experimental timeline with “TF” indicating days when mice were tested on the tail-flick test. B) The % preference for oxycodone-treated bottle did not differ as a function of sex, treated bottle or session. C) While across groups, oxycodone consuming mice consumed a higher dose compared to water consuming mice overall, across sexes, male mice consumed a lower dosage compared to female mice overall. D) Oxycodone consuming mice exhibited more naloxone-precipitated withdrawal jumps compared to water consuming mice overall. E) Naloxone-induced body weight loss did not differ as a function of the treated bottle or sex and the interaction was not significant. Data are expressed as mean ± S.E.M. (n = 7-8 per group). “*” indicates high (1 mg/ml) concentration oxycodone group vs. water group where ****p < 0.0001 “+” indicates male mice vs. female mice.