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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Neuropharmacology. 2021 Dec 15;205:108925. doi: 10.1016/j.neuropharm.2021.108925

Fig. 4. Fixed dose forced choice oxycodone prior to oxycodone TBC-DID leads to oxycodone bottle aversion.

Fig. 4.

A) The schematic shows the experimental timeline with “HP” and “OF” indicating days when mice were tested on the hot plate and open field activity meter test respectively. B) Oxycodone consuming mice had a lower % preference compared to water consuming mice overall. C) Oxycodone consuming mice consumed a higher dose compared to water consuming mice overall. Data are expressed as mean ± S.E.M. (n = 4-6 per group). “*” indicates high (1 mg/ml) concentration oxycodone group vs. water group where ****p < 0.0001.