Table 1:

Top Canonical Pathways Regulated by 2HF Treatment in BC cells

Top Canonical Pathways
Name	p-value
MCF7 (2HF vs. Control)
Protein Ubiquitination Pathway	3.34E-14
EIF2 signaling	2.08E-06
tRNA charging	4.69E-06
NRF2-mediated oxidative stress response	4.02E-05
Regulation of cellular mechanics by Calpain Protease	6.15E-05
MDA-MB231 (2HF vs. Control)
EIF2 signaling	5.82E-11
tRNA charging	1.88E-08
mTOR signaling	5.53E-07
Regulation of eIF4 and p70S6K signaling	7.27E-07
Aryl hydrocarbon receptor signaling	1.24E-06
SKBR3 (2HF vs. Control)
Protein Ubiquitination Pathway	1.73E-15
EIF2 signaling	5.68E-10
Regulation of eIF4 and p70S6K signaling	6.13E-07
Huntington Disease Signaling	2.10E-06
Sirtuin Signaling Pathway	6.73E-06