Table 1.

Descriptive analysis of adverse events of ivermectin in clinical trials comparing standard (up to 400 µg/kg) vs. high dose (> 400 µg/kg) of ivermectin

	Condition under study	Ivermectin dosage (µg/kg)	Adverse effects rate (%)	Odds ratio or risk difference (95% CI)
Kamgno et al. [70]	Onchocerciasis			0.96 (0.64–1.44)
	High dose	800	14.8
	Standard dose	150	15
Munoz et al. [33]	Healthy volunteers			0.907 (0.369–2.228)
	High dose	401–700	16
	Standard dose	200–400	17
Smit et al. [95]	Malaria			6·9% (− 1·9 to 15·7)
	High dose	600	11
	Standard dose	300	4
Wimmersberger et al. [33]	Trichuriasis			1.346 (0.532–3.405)
	High dose	600	27
	Standard dose	100–400	22