Fig. 7.

The bioavailability radar with the pink area. It represents the optimal range for physicochemical properties for oral bioavailability. Lipophilicity (− 0.7 < XlogP3 < + 0.5), size (150 < MW < 500 g/mol), polarity (20A² <TPSA <130A²), Insolubility (0 < Log S (ESOL) < 6), Insaturation (0.25 < Fraction Csp³ < 1), and flexibility (number of rotatable bonds < 9). The compounds, A Curcumin, B Trans-resveratrol, C Quercetin, and D (1 s,4 s)-Eucalyptol, are predicted orally bioavailable