Table 11.
The predicted toxicity for curcumin, trans-resveratrol, quercetin and (1 s,4 s)-eucalyptol using: (1) ProTox-II and (2) Pred-hERG softwares
| Curcumin | Trans-resveratrol | Quercetin | (1 s,4 s)-Eucalyptol | |
|---|---|---|---|---|
| (1) ProTox-II | ||||
| Predicted LD50 (mg/kg) | 2000 | 1560 | 159 | 2480 |
| Predicted toxicity class | 4 | 4 | 3 | 5 |
| Average similarity (%) | 100 | 69.97 | 100 | 100 |
| Prediction accuracy (%) | 100 | 68.07 | 100 | 100 |
| (2) Pred-hERG | ||||
| Prediction/Potency | Non-cardiotoxic | Non-cardiotoxic | Non-cardiotoxic | Potential cardiotoxic (Weak or moderate) |
| Confidence (%) | 70 | 60 | 60 | 80 |
| Applicability domain (AD) | Yes (Value = 0.28 and limit = 0.26) | No (Value = 0.21 and limit = 0.26) | No (Value = 0.19 and limit = 0.26) | No (Value = 0.16 and limit = 0.26) |