Table 8.

Prediction of the main pharmacokinetics parameters for curcumin, trans-resveratrol, quercetin and (1 s,4 s)-eucalyptol. These include gastrointestinal absorption, blood-brain barrier (BBB) penetration, effect on permeability glycoprotein (P-gp) and cytochromes P450 (CYP) major isoenzymes and skin permeation (log K_p)

	Curcumin	Trans-resveratrol	Quercetin	(1 s,4 s)-Eucalyptol
GI absorption	High	High	High	High
Blood-brain barrier (BBB) permeant	No	Yes	No	Yes
P-gp substrate	No	No	No	No
CYP1A2 inhibitor	No	Yes	Yes	No
CYP2C19 inhibitor	No	No	No	No
CYP2C9 inhibitor	Yes	Yes	No	No
CYP2D6 inhibitor	No	No	Yes	No
CYP3A4 inhibitor	Yes	Yes	Yes	No
Log Kp (skin permeation)	−6.28 cm/s	−5.47 cm/s	−7.05 cm/s	− 5.30 cm/s