Table 1.
L–R differential methylation of ion channels in in-vivo and in-silico studies
| More methylated right | More methylated left | ||
|---|---|---|---|
| Gene symbol* | Channel function | Gene symbol* | Channel function |
| Ion channels from in-vivo assays | |||
| CHRNE | Depolarization | ASIC2 | Depolarization |
| HTR1A | Depolarization | CACNA1A | Depolarization |
| PIEZO2 | Depolarization | CACNA2D2 | Depolarization |
| RYR3 | Depolarization | CATSPERD | Depolarization |
| TRPC7 | Depolarization | PKD1L1 | Depolarization |
| TRPM8 | Depolarization | TRPM4 | Depolarization |
| ANO2 | Hyperpolarization | ANO3 | Hyperpolarization |
| ATP1A3 | Hyperpolarization | ANO5 | Hyperpolarization |
| ATP6V1C2 | Hyperpolarization | CLCN1 | Hyperpolarization |
| ATP6V1H | Hyperpolarization | CLIC5 | Hyperpolarization |
| GABBR1 | Hyperpolarization | GABBR2 | Hyperpolarization |
| KCNA7 | Hyperpolarization | GABRA5 | Hyperpolarization |
| KCNB1 | Hyperpolarization | GABRD | Hyperpolarization |
| GABRG1 | Hyperpolarization | ||
| KCNH2 | Hyperpolarization | ||
| KCNIP3 | Hyperpolarization | ||
| KCNJ18 | Hyperpolarization | ||
| KCNK9 | Hyperpolarization | ||
| KCNN1 | Hyperpolarization | ||
| VDAC2 | Hyperpolarization | ||
| Ion channels from in-silico assays | |||
| CACNA1D | Depolarization | CACNA2D2 | Depolarization |
| CACNA1H | Depolarization | CACNA2D4 | Depolarization |
| CACNA1I | Depolarization | CHRNA1 | Depolarization |
| CACNB2 | Depolarization | CNGA1 | Depolarization |
| CACNG4 | Depolarization | HCN1 | Depolarization |
| CACNG6 | Depolarization | P2RX4 | Depolarization |
| CHRNA6 | Depolarization | PKD2 | Depolarization |
| CHRNB1 | Depolarization | RYR1 | Depolarization |
| CHRNB2 | Depolarization | SCN11A | Depolarization |
| CNGA3 | Depolarization | SCNN1A | Depolarization |
| GRIA1 | Depolarization | TRPM3 | Depolarization |
| HVCN1 | Depolarization | CFTR | Hyperpolarization |
| LRRC8D | Depolarization | CLCN1 | Hyperpolarization |
| LRRC8E | Depolarization | CLCNKB | Hyperpolarization |
| MCOLN2 | Depolarization | KCNA1 | Hyperpolarization |
| MCOLN3 | Depolarization | KCNA5 | Hyperpolarization |
| PKD2L2 | Depolarization | KCNC3 | Hyperpolarization |
| SCN3B | Depolarization | KCNH7 | Hyperpolarization |
| SCN9A | Depolarization | KCNH8 | Hyperpolarization |
| SCNN1G | Depolarization | KCNJ9 | Hyperpolarization |
| TRPA1 | Depolarization | KCNMA1 | Hyperpolarization |
| TRPC2 | Depolarization | KCNS2 | Hyperpolarization |
| TRPC3 | Depolarization | ||
| TRPM2 | Depolarization | ||
| TRPM6 | Depolarization | ||
| TRPV3 | Depolarization | ||
| TRPV4 | Depolarization | ||
| TRPV6 | Depolarization | ||
| CLIC3 | Hyperpolarization | ||
| GABRA2 | Hyperpolarization | ||
| GABRG1 | Hyperpolarization | ||
| GABRP | Hyperpolarization | ||
| GABRR1 | Hyperpolarization | ||
| GLRA3 | Hyperpolarization | ||
| GLRB | Hyperpolarization | ||
| KCNA2 | Hyperpolarization | ||
| KCNA6 | Hyperpolarization | ||
| KCNA7 | Hyperpolarization | ||
| KCNG1 | Hyperpolarization | ||
| KCNH1 | Hyperpolarization | ||
| KCNH4 | Hyperpolarization | ||
| KCNH6 | Hyperpolarization | ||
| KCNJ15 | Hyperpolarization | ||
| KCNJ2 | Hyperpolarization | ||
| KCNJ5 | Hyperpolarization | ||
| KCNJ6 | Hyperpolarization | ||
| KCNK3 | Hyperpolarization | ||
| KCNK4 | Hyperpolarization | ||
| KCNK5 | Hyperpolarization | ||
| KCNN4 | Hyperpolarization | ||
| KCNQ3 | Hyperpolarization | ||
| KCNQ4 | Hyperpolarization | ||
| KCNS1 | Hyperpolarization | ||
| KCNS3 | Hyperpolarization | ||
| KCNT2 | Hyperpolarization | ||
*HUGO Gene Nomenclature Committee (HGNC)