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. 2022 Feb 5;10:16. doi: 10.1186/s40478-022-01319-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Conceptual diagram illustrating the white matter tracts studied and their biological associations. Top panel: Genu as the white matter tract studied for systemic vascular health; parahippocampal cingulum (CGH) and inferior temporal white matter (ITWM) studied for temporal lobe pathologies. A Association of Genu white matter NODDI measures with systemic vascular health in MCSA. B Association of CGH and ITWM NDI measures with tau deposition in ADRC. Tau values were log transformed. C Association of CGH and ITWM NDI measures with FDG TDP-43 signature in MCSA. Inferior temporal to medial temporal (IMT) and frontal supra orbital ratio (IMT/FSO) was used as FDG TDP-43 signature