Table 3.
Characteristics of autopsy cases in our dataset with TDP-43 information available
| Cohort | Age/sex | Clinical diagnosis | Hypertension (CMCa in MCSA) | Amyloid PET (+)b (SUVR) | Tau PET (+)c (SUVR) | Neurodege-neration (+)d (HVa) | TDP-43 (+)e (FDG TDP-43 signature IMT/FSO) | Genu (ISOVF, NDI) | ITWM NDI | CGH NDI | MMSE | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case 1 | MCSA | 85M |
Multi-domain MCI |
+ (4) | − (1.28) | − (1.24) | + (− 1.48) | + (0.81) | 0.22, 0.49 | 0.45 | 0.48 | 27 |
| Case 2 | MCSA | 79M | Amnestic MCI | + (2) | + (2.12) | − (1.19) | + (− 1.72) | + (0.96) | 0.19, 0.42 | 0.37 | 0.39 | 26 |
| Case 3 | MCSA | 83M | Control | + (2) | − (1.3) | − (1.16) | − (− 0.10) | + (1.09) | 0.23, 0.48 | 0.45 | 0.42 | 30 |
| Case 4 | MCSA | 82F | Dementia | + (2) | + (2.92) | + (1.73) | + (− 1.44) | − | 0.22, 0.52 | 0.44 | 0.46 | 24 |
| Case 5 | ADRC | 81M | AD | + | + (2.41) | + (1.73) | + (− 1.88) | − (0.90) | 0.22, 0.46 | 0.45 | 0.42 | 23 |
| Case 6 | ADRC | 74F | AD | − | + (2.16) | − (1.15) | + (− 0.91) | − (0.76) | 0.11, 0.46 | 0.45 | 0.43 | 14 |
| Case 7 | ADRC | 80M | AD | − | + (2.98) | + (2.08) | + (− 3.21) | + | 0.17, 0.59 | 0.48 | 0.45 | 20 |
| Case 8 | ADRC | 75M | AD | − | + (2.68) | + (1.47) | + (− 1.83) | − (0.96) | 0.18, 0.51 | 0.47 | 0.45 | 22 |
| Case 9 | ADRC | 76M | AD | + | + (2.44) | + (2.31) | + (− 2.04) | + (0.96) | 0.26, 0.53 | 0.47 | 0.46 | 20 |
aCMC—cardiovascular and metabolic conditions by ascertainment of seven conditions from REP: hypertension, hyperlipidemia, cardiac arrhythmias, coronary artery disease, congestive heart failure, diabetes mellitus, and stroke
bAmyloid positivity (+) = SUVR ≥ 1.48; SUVR—standard uptake value ratio
cTau positivity (+) = SUVR ≥ 1.25
dNeurodegeneration positivity (+) = Hippocampal volume adjusted for TIV (HVa) from MRI ≤ − 0.76
eTDP-43 positivity (+) = presence of TDP-43 immunoreactive neuronal cytoplasmic inclusions, dystrophic neurites, or neuronal intranuclear inclusions in the amygdala in autopsy brain; TDP-43 = trans-active response DNA-binding protein of 43 kDa
ISOVF, isotropic volume fraction; CGH, parahippocampal cingulum; ITWM, inferior temporal white matter, NDI, neurite density index, IMT/FSO, inferior temporal to medial temporal (IMT) to frontal supra orbital (FSO) ratio
Mean (SD) NODDI measures among the populations investigated: For MCSA: Genu ISOVF = 0.11(0.03), Genu NDI = 0.54(0.04), CGH NDI = 0.49 (0.03), ITWM NDI = 0.49(0.04) and for ADRC: Genu ISOVF = 0.13(0.03), Genu NDI = 0.52(0.04), CGH NDI = 0.46 (0.03), ITWM NDI = 0.47(0.03))