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. 2022 Feb 5;19:34. doi: 10.1186/s12974-022-02401-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Running exercise increased the total number of microglia in the DG of APP/PS1 mice. a Representative immunohistochemical staining of IBA1-labeled microglia in the DG, CA1, and CA3 regions of WT_Sed, AD_Sed, WT_Run, and AD_Run mice. Scale bar: 40 μm. b, c Quantification results of the total number and density of IBA1⁺ microglia in the DG, CA1, and CA3 regions of WT_Sed, AD_Sed, WT_Run, and AD_Run mice. d Representative binary images showing IBA1⁺ microglia with the uniform protocol in the DG of WT_Sed, AD_Sed, WT_Run, and AD_Run mice. e, f Quantification results of endpoints/microglia and process length/microglia. n = 4–5. Data are shown as the mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001