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. 2022 Feb 5;20:69. doi: 10.1186/s12951-022-01278-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 13 — a Schematic diagram of the anticancer mechanism of multifunctional BP@Cu@PEG-RGD hybrid nanomaterials in vivo [133]. b Relative tumor volume after different treatments on day 14 [133]. c Inhibitory rates of B16F10 tumors at day 14 post-treatment [133]. d MIP PET images of B16F10 tumor-bearing mice after 2 weeks of treatment with saline or BP@Cu_0.4@PEG-RGD, respectively. PET images were taken at 30 and 40 h after intravenous injection of saline or BP@⁶⁴Cu@PEG-RGD. The white circles denote the tumor sites. Reproduced with permission. [133]

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