Table 2.

Other metabolites formed by PQ enantiomers as observed in different mouse tissues

Mass (M + 1)	Retention time (min)	Putative identity	Key findings
274.1544	2.35	Hydroxylation and quinone-imine formation	Formed from both enantiomers, found only in the plasma
332.1604	7.7	Acetylated dihydroxy-PQ quinone-imine	Formed from RPQ and found in plasma and liver
422.1929	4.9	Glycosylated primaquine	Higher amount formed from SPQ than RPQ; found in the plasma and liver
436.1992	2.17	Primaquine glucuronide	Present only in the plasma with no remarkable enantiomeric difference in the profiles
452.2027	1.9	Hydroxy-primaquine glucuronide	Formed only from the SPQ enantiomer and found only in the in the plasma
452.2027	9.26	Hydroxy-primaquine glucuronide	Formed from both enantiomers and found in the liver, RBC, kidneys and lungs. No remarkable enantioselectivity
480.1989	7.9	Primaquine-N-carbamoyl glucuronide	Formed from both enantiomers; found only in the plasma