Table 1:
Clinicopathological features of patients with pancreatic ductal adenocarcinoma stratified by Das-1 expression
| Clinical or pathologic feature | Total N |
Das-1 expression | P value | |
|---|---|---|---|---|
| Negative | Positive | |||
| All cases | 74 | 19 | 55 | |
| Gender | 0.785 | |||
| Male | 28 | 8 (42%) | 20 (36%) | |
| Female | 46 | 11 (58%) | 35 (64%) | |
| Age (years) | 0.100 | |||
| Mean | 65.8 | 62.5 | 67.0 | |
| SD | 10.2 | 9.7 | 10.3 | |
| Tumor size (cm) | 0.446 | |||
| Mean | 3.1 | 2.9 | 3.1 | |
| SD | 0.9 | 0.9 | 0.9 | |
| Tumor stage | 0.671 | |||
| pT1 | 1 | 0 (0%) | 1 (1.8%) | |
| pT2 | 7 | 1 (5.3%) | 6 (11%) | |
| pT3 | 65 | 18 (95%) | 47 (85%) | |
| pT4 | 1 | 0 (0%) | 1 (1.8%) | |
| Nodal stage | 0.021 | |||
| pN0 | 16 | 8 (42%) | 8 (11%) | |
| pN1 | 58 | 11 (58%) | 47 (89%) | |
| Stage | 1.000 | |||
| IA | 1 | 0 (0%) | 1 (1.8%) | |
| IB | 1 | 0 (0%) | 1 (1.8%) | |
| IIA | 14 | 8 (42%) | 6 (11%) | |
| IIB | 57 | 11 (58%) | 46 (84%) | |
| III | 1 | 0 (0%) | 1 (1.8%) | |
| Histological grade** | ||||
| Low | 35 | 10 (53%) | 25 (45%) | 0.606 |
| High | 39 | 9 (47%) | 30 (55%) | |
| Lymphatic invasion | ||||
| (−) | 25 | 8 (42%) | 17 (31%) | 0.408 |
| (+) | 49 | 11 (58%) | 38 (69%) | |
| Vascular invasion | ||||
| (−) | 26 | 9 (47%) | 17 (31%) | 0.266 |
| (+) | 48 | 10 (53%) | 38 (69%) | |
| Perineural invasion | ||||
| (−) | 6 | 1 (5.3%) | 5 (9.1%) | 1.000 |
| (+) | 68 | 18 (95%) | 50 (91%) | |
| Resection margin status | ||||
| Negative | 26 | 11 (58%) | 15 (27%) | 0.259 |
| Positive | 48 | 8 (42%) | 40 (73%) | |
**
low grade: well and moderately differentiated, high grade: poorly differentiated and undifferentiated