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High CGRP expression promotes the malignant transformation of PNECs through the SHH signaling pathway. PNECs regulate group 2 innate lymphoid cells (ILC2s) through CGRP in small cell lung cancer which may affect the immune status of the tumor microenvironment. Moreover, CGRP protects stem cells from apoptosis by blocking the G0/G1 phase of the cell cycle to S phase through the SHH signaling pathway.
