Table 2.
Patients with giant parathyroid adenoma, clinical characteristics, tumor pathologies and postoperative complications.
| Case report | Gender | Age (Years) | Side | Presentation | Ca (mg/dL)/PTH (ng/L) | Dimensions (mm) | Weight (g) | Pathology | Post-operative complications |
|---|---|---|---|---|---|---|---|---|---|
| Aggarwal et al., 2009 [22] | F | 33 | L | Edema, palpable nodule, bone pain, R humerus and R pelvic fracture | 10.6/762 | 95 × 50 × 35 | 102 | Chief cell adenoma | Symptomatic hypocalcemia |
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| Salehian et al., 2009 [23] | F | 53 | R | Edema, bone pain, weight loss, nausea, vomit | 14.63/1624 | 55 × 35 × 20 | 30 | PTA | No complication |
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| Sisodiya et al., 2011 [24] | F | 52 | R | Recurrent vomit | 17.03/598 | 39 × 20 × 17 | ND | ND | Hypocalcemia |
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| Asghar et al., 2012 [25] | F | 55 | L | Parathyroid crisis, palpable nodule | 23.05/1182 | 110 × 70 × 60 | ND | Cystic degeneration PTA, no lymph node metastasis | No complication |
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| Vilallonga et al., 2012 [26] | F | 19 | L | Parathyroid crisis | 14.23/1207 | Maximum diameter 30 | 70 | Intrathyroid PTA | No complication |
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| Neagoe et al., 2014 [27] | M/F/F | 57/60/33 | R/L/R | C 1: bone pain, abdominal pain, nausea, palpable nodule. C 2: parathyroid crisis, palpable nodule. C 3: recurrent renal calculi, brown tumor in tibia | C 1 : 3.54/1780 C 2 : 16.19/863 C 3 : 12.63/1174 | C 1 : 50 × 30 × 20 C 2 : 55 × 40 × 30 C3ND | C 1 : 30.6 C 2 : 35.2 C 3:>30 | 2 PTA; 1 partially cystic PTA | C 1: hungry bone syndrome C 2: mild hypocalcemia and hungry bone syndrome C 3: mild hypocalcemia |
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| Haldar et al., 2014 [28] | F | 61 | L | Asymptomatic | 12.71/179.2 | 65 × 30 × 15 | 12 | PTA | No complication |
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| Garas et al., 2015 [29] | F | 53 | L | Palpable nodule, bone pain | 15.95/4038 | Maximum diameter 70 | 27 | Chief cell PTA | No complication |
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| Case report | Gender | Age (Years) | Side | Presentation | Ca (mg/dL)/PTH (ng/L) | Dimensions (mm) | Weight (g) | Pathology | Post-operative complications |
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| Rutledge et al., 2016 [30] | F | 21 | R | Neck mass enlargement, constipation, palpable nodule | 10.94/1305.1 | 80 × 55 × 30 | 58.8 | Atypical PTA | Symptomatic hypocalcemia, hungry bone syndrome |
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| Krishnamurthy et al., 2016 [31] | M | 50 | L | Recurrent acute pancreatitis crisis, palpable neck mass | 11.1/669 | Maximum diameter 60 | 20 | PTA | Hipocalcemia |
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| Castro et al., 2017 [32] | F | 40 | L | Asymptomatic palpable nodule | 13.43/825 | 64 × 16 × 20 | 10.8 | PTA | Hypocalcemia |
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| Sahsamanis et al., 2017 [33] | F | 42 | L | Abdominal pain | 10.42/151 | 33 × 20 × 14 | 5.39 | PTA | No complication |
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| Mantzoros et al., 2018 [34] | F | 73 | R | Enlargement of neck size, bone pain | 14.55/1629 | 50 × 25 × 25 | 30 | PTA | Hungry bone syndrome |
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| Migliore et al., 2013 [35] | F | 65 | R | Persistent hypercalcemia | Both elevated | ― | 95 | PTA | No complication |
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| Taghavi Kojidi et al., 2016 [36] | M | 70 | Middle | Anorexia, nausea, bone pain, constipation, symptomatic nephrolithiasis, polydipsia | 14.55/930 | ― | 75 | Active parathyroid lesion | Hypocalcemia |
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| Pecheva et al., 2016 [37] | F | 72 | R | Depression, severeosteoporosis (T = − 3,2) | 12.1/250.8 | ― | 19 | PTA | Hoarseness, cough |
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| Talukder et al., 2017 [38] | F | 49 | Middle | Brown tumor | 14.07/1000 | 40 × 30 × 20 | 12 | Neuroendocrine cell tumor | No complication |
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| Garuna Murthee et al., 2018 [39] | M | 72 | Middle | Anorexia, lethargy, abdominal cramps, constipation, weight loss | 15.19/1867.1 | Maximum diameter 78 | 220 | Intrathymic PTA | No complication |
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| Miller et al., 2019 [40] | M | 53 | Middle | Asymptomatic nephrolithiasis | 11.22/179.2 | 80 × 30 × 30 | 30.9 | PTA | No complication |
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| P liu et al., 2020 [41] | M | 79 | L/R | Obstructive right nephropathy, and acute kidney injury secondary to hypercalcemia | 13.19/420.5 | L: 50 × 25 × 12 R: 48 × 22 x 10 | L:8101 R:7339 | PTA | No complication |
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| Giuseppe Evola et al., 2020 [42] | F | 52 | Musculoskeletal pain, constipation, polyuria, pathological fracture of bilateral femur | 12.5/27.47 | 65 × 50 x 30 | 90 | PTA | No complication | |
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| Alvarez JC et al., 2021 [our case] | F | 55 | R | Polyarthralgias, pathological fracture of humerus, brown tumor of humerus | 14.9/1973 | Maximum diameter 5 | 16 | PTA | Hungry bone syndrome |