(b).

Subfamily	Gene	Localization	PAMP recognized	Activator	Effector response
NLRA	CIITA	Cytoplasm		IFN-γ
NLRB	NAIP	Cytoplasm	Triacylated lipopeptides	Flagellin	IL-6, TNF-α
NLRC	NOD1	Cytoplasm	Di/triacylated lipopeptides	DAP	IL-6, TNF-α, MCP-1, RANETS
	NOD2	Cytoplasm	dsRNA	MDP	IFN-β
	NLRC3	Cytoplasm	LPS	Unknown	IL-6, TNF-α, IFN-β, IP-10
	NLRC4	Cytoplasm	Flagellin	Rod protein, flagellin	TNF-α
	NLRC5	Cytoplasm	Diacylated lipopeptides	IFN-γ, IFN-β	TNF-α, IL-6, IL-8, MCP-1, RANTES
	NLRX1	Cytoplasm	ssRNA	Unknown	IFN-α
NLRP	NLRP1	Cytoplasm	ssRNA	Lethal Toxin, MDP	IFN-α
	NLRP2	Cytoplasm	CpG DNA	Unknown	IFN-α
	NLRP3	Cytoplasm	Profilin, flagellin	ATP, Alum, Asbestos, Silica, ROS	IL-12, TNF-α
	NLRP4	Cytoplasm	Profilin	Unknown	IL-12p40, IFN-α
	NLRP5	Cytoplasm	23s rRNA	Unknown	IL-6, IL-12p40
	NLRP6	Cytoplasm	Colitis, colorectal tumorigenesis	Unknown	NF-κB, ERK, IFN-α,
	NLRP7	Cytoplasm	Unknown	Lipopeptides	IL-18, IL-1β
	NLRP8	Cytoplasm	Unknown	Unknown	Unknown
	NLRP9	Cytoplasm	Unknown	Unknown	Unknown
	NLRP10	Cytoplasm	Unknown	Unknown	NF-κB, IL-1β
	NLRP11	Cytoplasm	Unknown	Unknown	Unknown
	NLRP12	Cytoplasm	Unknown	Yersinia	NF-κB
	NLRP13	Cytoplasm	Unknown	Unknown	Unknown
	NLRP14	Cytoplasm	Unknown	Spermatogenesis	Unknown