Figure 8.

Curcumin treatment reduces ubiquitination and NF-κB activity in muscle tissue of tumor-bearing mice. (a–c) Statistical analysis of atrogin-1, MuRF-1, and NF-κB mRNA expression of mouse gastrocnemius in three groups. (d) Western blot bands of atrogin-1 and MuRF-1 protein in gastrocnemius of the three groups. (e) Western blot bands of P65 and P-P65 protein in gastrocnemius of the three groups. (f–i) Statistical analysis of atrogin-1, MuRF-1, P-65, and PP-65 protein expressions in gastrocnemius of three groups of mice. NS: not significant; ^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001 by t-test, compared to the model group. Data was shown as mean ± standard errors of the mean.