Table 1.
Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities and log P values of the title compounds
| Compound | IC50 ± SEM (µM)a | Selectivity indexb | log P | |
|---|---|---|---|---|
| AChE | BuChE | |||
| 1 | 66.7 ± 1.7 | > 100 | > 1.50 | 1.36 |
| 2 | 23.3 ± 1.2 | > 100 | > 4.29 | 2.78 |
| 3 | 20.1 ± 0.9 | > 100 | > 4.98 | 3.17 |
| 4 | > 100 | > 100 | – | |
| 5 | > 100 | > 100 | – | |
| 6 | > 100 | > 100 | – | |
| 7 | > 100 | > 100 | – | |
| Rivastigmine | 1.82 ± 0.13 | – | 1.34 | |
| Huperzine A | 0.045 ± 0.01 | – | 1.22 | |
aIC50 values represent the means ± SEM of three parallel measurements (P < 0.05)
bSelectivity index = IC50 (BuChE)/IC50 (AChE). “–” no determination