Table 1.

Classification schemes of upper and lower airway disease

Current allergy-dependent classification
Allergic disease	Non-allergic disease
Allergic asthma	Nasal polyposis
Allergic rhinitis (local or systemic)	AERD
ABPA	Non-allergic rhinitis
	Non-allergic asthma
Proposed IgE-dependent classification
IgE-mediated disease	Non–IgE-mediated disease
Th2 asthma (allergic, EIA, AERD, late-onset eosinophilic)	Some non-allergic rhinitis subgroups
ABPA	CRSsNP
Allergic rhinitis	Non-allergic asthma:
Some non-allergic rhinitis subgroups	•Neutrophilic
CRSwNP (nasal polyposis)	•Obesity associated
	•Smoking associated
	•Very late onset
	• Environmental asthma due to chemical or pollution exposure

ABPA allergic bronchopulmonary aspergillosis, AERD aspirin-exacerbated respiratory disease, CRSsNP chronic rhinosinusitis without nasal polyps, CRSwNP chronic rhinosinusitis with nasal polyps, EIA exercise-induced asthma, IgE immunoglobulin E, Th2 T helper 2