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. 2021 Oct 23;50(1):17–31. doi: 10.1007/s10827-021-00802-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Position of the modeled patches in the whole brain: Real (green) and S-Realistic (blue) surfaces. Axes notation: R - Right, A - Anterior, S - Superior. B Detail of the real and three surrogate surfaces. Electrode contacts (in yellow) are numbered from the 1 on the mesial side to 9 on the lateral side. The distance between the neighboring contacts is 3.5 mm. Surface coloring shows the position of the epileptogenic zone (EZ). C Minimal distance of every electrode contact from the part of the cortical surfaces included in the simulation (green) and from the subcortical structures or the part of the cortical surface not included in the simulation (gray). D Spatial representation of the gain matrix row for contact 3. Blue colors marks the positive weighting, red color negative. E Fraction of the gain matrix associated with the area of given size for monopolar (blue) and bipolar (red) referencing. See the main text (Sect. 3.3) for further details. Inset: area associated with 50% of the gain matrix for monopolar (blue) and bipolar (red) referencing. Note the different scales for monopolar and bipolar referencing