Table 1.
Baseline Characteristics of the Study Population Stratified by Adipose Tissue Phenotype
| Overall (n = 2064) | High VAT / High LF (n=740) | High VAT / Low LF (n=293) | Low VAT / High LF (n=293) | Low VAT / Low LF (n=738) | P-Value | |
|---|---|---|---|---|---|---|
| Age, median (IQR) | 44 (37,53) | 47 (40, 54) | 48 (39, 55) | 42 (35, 51) | 41 (35, 50) | <.001 |
| Female, No. (%) | 1113 (54) | 400 (54) | 157 (54) | 157 (54) | 399 (54) | .10 |
| Race, No. (%) | ||||||
| White | 665 (32) | 254 (34) | 76 (26) | 96 (33) | 239 (32) | .11 |
| Black | 976 (47) | 329 (45) | 160 (55) | 135 (46) | 352 (48) | .04 |
| Hispanic | 378 (18) | 140 (19) | 55 (19) | 50 (17) | 133 (18) | .91 |
| Other | 45 (2) | 17 (2) | 2 (1) | 12 (4) | 14 (2) | .04 |
| Weight, median (IQR)-kg | 82 (70, 97) | 94 (84, 109) | 88 (79, 102) | 77 (68, 87) | 70 (62, 81) | <.001 |
| Height, median (IQR)-cm | 168 (160, 175) | 168 (160, 175) | 168 (161, 175) | 166 (159, 173) | 168 (160, 175) | .08 |
| Body Mass Index,median (IQR)-kg/m2 | 29 (25, 34) | 33 (30, 38) | 31 (28, 35) | 27 (25, 31) | 25 (23, 28) | <.001 |
| Waist Circumference,median (IQR)-cm | 97 (87,108) | 108 (100, 117) | 103 (96, 112) | 93 (86, 99) | 87 (79, 93) | <.001 |
| VAT, median (IQR)-kg | 2 (2, 3) | 3 (2, 3) | 3 (2, 3) | 2 (1, 2) | 1 (1,2) | <.001 |
| LF, median (IQR)-% | 4 (2, 67) | 8 (5,13) | 2 (2,3) | 5 (4,8) | 2 (1,3) | <.001 |
| DEXA | ||||||
| Fat mass,median (IQR)-kga | 25 (19, 33) | 32 (26, 41) | 28 (24, 36) | 23 (18, 29) | 19 (14, 24) | <.001 |
| Lean mass,median (IQR)-kga | 54 (46, 64) | 59 (50, 68) | 57 (48, 66) | 52 (43, 60) | 49 (42, 60) | <.001 |
| Lower body fat, median (IQR)-kga | 9 (6, 12) | 10 (8, 14) | 10 (8, 13) | 8 (6, 11) | 7 (5, 10) | <.001 |
| Truncal fat,median (IQR)-kga | 13 (9, 17) | 17 (14, 21) | 14 (12, 18) | 11 (9, 14) | 9 (6, 11) | <.001 |
| Diabetes Mellitus, No. (%)b | 231 (11) | 147 (20) | 34 (12) | 24 (8) | 26 (4) | <.001 |
| Hypercholesterolemi a, No. (%) | 279 (14) | 134 (18) | 47 (16) | 42 (14) | 56 (8) | <.001 |
| Low High-density lipoprotein cholesterol, No. (%) | 871 (42) | 407 (55) | 133 (45) | 119 (41) | 212 (29) | <.001 |
| Metabolic Syndrome, No. (%) | 734 (36) | 453 (61) | 121 (41) | 85 (29) | 75 (10) | <.001 |
| Current Smoker, No. (%)c | 515 (25) | 164 (23) | 64 (22) | 67 (23) | 220 (30) | .003 |
| Prior Cardiovascular disease, No. (%) | 136 (7) | 55 (7) | 29 (10) | 13 (4) | 39 (5) | .02 |
| Physical Activity, median (IQR)-MET min/weekd | 144 (0, 585) | 99.5 (0, 444) | 120 (0,560) | 119 (0,560) | 239 (0, 720) | <.001 |
a
n = 2020
b
n = 2063
c
n = 2059
d
n = 1918