Table 2.

Multivariable-adjusted linear and logistic regression models of relation of VAT-LF phenotypes to biomarkers of cardiometabolic disease

	High VAT-High LF	High VAT-Low LF	Low VAT-High LF
Biomarker	β-coefficient (standard error)	β-coefficient (standard error)	β-coefficient (standard error)
Glucose (mg/dL)	0.08 (0.01)*	0.02 (0.01)	0.05 (0.01)*
HOMA-IR (units)	0.68 (0.04)*	0.27 (0.05)*	0.32 (0.05)*
Adiponectin (ng/mL)	−0.35 (0.03)*	−0.19 (0.04)*	−0.26 (0.04)*
hs-CRP (mg/dL)	0.35 (0.07)*	0.26 (0.09)*	0.27 (0.08)*
Myeloperoxidase (ng/mL)	0.05 (0.03)*	0.06 (0.03)*	−0.002 (0.03)
LDL-C (mg/dL)	0.08 (0.02)*	0.08 (0.03)*	0.04 (0.03)
LDL Small (nm)	0.51 (0.08)*	0.35 (0.09)*	0.31 (0.08)*
Triglycerides (mg/dL)	0.47 (0.04)*	0.18 (0.04)*	0.29 (0.04)*
VLDL Large (nm)	0.91 (0.05)*	0.32 (0.06)*	0.60 (0.06)*
HDL-C (mg/dL)	−0.14 (0.02)*	−0.10 (0.02)*	−0.07 (0.02)*
HDL Large (nm)	−0.38 (0.03)*	−0.22 (0.04)*	−0.20 (0.03)*
Aortic Wall Thickness (mm)	0.09 (0.02)*	0.06 (0.02)*	0.03 (0.02)
Biomarker	Odds Ratio (95% CI)	Odds Ratio (95% CI)	Odds Ratio (95% CI)
Hypertension	2.1 (1.5, 2.9)*	1.6 (1.1, 2.3)*	1.5 (1.1, 2.2)*
Metabolic Syndrome	6.6 (2.2, 5.9)*	3.3 (2.3, 4.7)*	2.9 (2.0, 4.1)*
Diabetes Mellitus	3.6 (2.2, 5.9)*	1.9 (1.1, 3.2)*	2.2 (1.2, 3.3)*

Data presented are β-coefficients (standard error) that represent the unit increase in the outcome for each phenotype group or odds ratios (95% CI) that represent the odds of the outcome for each phenotype group of High VAT-Low LF or Low VAT-High LF

Model adjusted for age + sex + race + menopausal status (women only) + body mass index (referent low VAT-low LF)

^*P < 0.05

LF, liver fat; HOMA-IR, homeostasis model assessment of insulin resistance; LDL-C, low density lipoprotein cholesterol; HDL-C, high density lipoprotein cholesterol; hs-CRP, high sensitivity C-reactive protein; VAT, visceral adipose tissue; VLDL, very low density lipoprotein