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. Author manuscript; available in PMC: 2023 Feb 3.
Published in final edited form as: Structure. 2021 Oct 21;30(2):263–277.e5. doi: 10.1016/j.str.2021.10.002

Figure 3. InsPs stably bind to the N-domain of Arr1.

Figure 3.

(A) InsP6 binds to the concave, basic region of the N-domain. (B) InsP3 binds to the concave, basic region of the N-domain. All noted interactions are 4.0 Å or less. (C) Comparison of the relative location of the basal C-tail, InsP6, and InsP3. (D) Arr1 structure showing the positions of A401 and T396 (left); cwEPR data of Arr1 at the two positions on the C-tail, T396 (middle) and A401 (right). Measurements from both T396 and A401 show increased flexibility upon InsP-binding.