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. Author manuscript; available in PMC: 2023 Feb 3.
Published in final edited form as: Cell Stem Cell. 2022 Jan 21;29(2):232–247.e7. doi: 10.1016/j.stem.2021.12.009

Figure 2. The microbiota regulates HSC response in different stress conditions.

Figure 2.

(A–C) Cell lineages, Lin− cells, MPPs and HSCs in the BM of control and ABX-treated mice at day 24 after sublethal TBI (n = 4–5). See also Figure S2G.

(D–E) BMT and HSCT analyses of control and ABX-treated mice under steady state or at day 24 after sublethal TBI (n = 4–9).

(F) HSCs in the blood and BM of control and ABX-treated mice following G-CSF treatment (n = 6–8).

(G–I) LSK cells and HSCs in the BM of control and ABX-treated mice following E. coli infection or LPS challenge (n = 3–4). See also Figure S2H–I.

* p < 0.05, ** p < 0.01, *** p < 0.001. Error bars, mean ± SEM.

See also Figure S3 for niche, HSC localization, and cytokine availability analyses.