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. Author manuscript; available in PMC: 2023 Feb 3.
Published in final edited form as: Cell Stem Cell. 2022 Jan 21;29(2):232–247.e7. doi: 10.1016/j.stem.2021.12.009

Figure 6. Iron availability regulates HSC self-renewal and differentiation during regeneration.

Figure 6.

(A–C) Neutrophils, Lin− cells, HSCs, and long-term reconstitution following BMT in mice fed with normal, iron-low or iron-deficient food, at day 12 after 5FU challenge (n= 8–11). See also Figure S7D–G.

(D–E) Neutrophils, Lin− cells, HSCs and HSC cell cycling in the BM of ABX-treated mice fed with normal, iron-low or iron-deficient food, at day 12 after 5FU treatment (n = 4–9).

(F–H) Neutrophils, Lin− cells, HSCs, and long-term reconstitution following BMT in control and ABX-treated mice injected with PBS or iron dextran, at day 12 after 5FU challenge (n = 5–14). See also Figure S7H–L.

* p < 0.05, ** p < 0.01, *** p < 0.001; ns, not significant. Error bars, mean ± SEM.

See also Figure S7 for steady-state analyses of the iron deficiency model.