Table 1.
Univariate analysis of donor and recipient characteristics for DMEK and DSAEK cases with and without early graft failure.
| DMEK cases with early failure | DMEK cases without early failure | P-value | DSAEK cases with early failure | DSAEK cases without early failure | P-value | |
|---|---|---|---|---|---|---|
| N | 109 | 10,481 | 104 | 18,389 | ||
| Donor Factors | ||||||
| Donor Age, years [mean (SD); range] | 65.2 (7.5); 44–81 | 63.7 (7.9); 6–80 | 0.05 | 60.2 (12.4); 14–78 | 55.9 (13.5); 2–80 | 0.001 |
| Cause of Death (%) | 0.80 | 0.004 | ||||
| Cancer | 30 (27.8) | 2431 (23.2) | 34 (33.0) | 3325 (18.1) | ||
| Cerebrovascular Accident | 11 (10.2) | 1058 (10.1) | 8 (7.8) | 1743 (9.5) | ||
| Heart disease | 37 (34.3) | 4185 (39.9) | 31 (30.1) | 7516 (40.9) | ||
| Respiratory disease | 15 (13.9) | 1338 (12.8) | 13 (12.6) | 1954 (10.6) | ||
| Trauma | 6 (5.6) | 472 (4.5) | 8 (7.8) | 1948 (10.6) | ||
| Other | 9 (8.3) | 997 (9.5) | 9 (8.7) | 1903 (10.3) | ||
| Initial ECD cells/mm2 [mean (SD)] | 2765 (299) | 2807 (279) | 0.12 | 2769 (312) | 2812 (304) | 0.15 |
| Post-cut ECD cells/mm2 [mean (SD)] | 2758 (265) | 2767 (265) | 0.78 | 2743 (247) | 2805 (288) | 0.04 |
| Death To cooling time, hours [median (IQR)] | 2.52 (1.59, 3.83) | 2.72 (1.90, 3.83) | 0.22 | 2.63 [1.71, 3.33] | 2.70 [1.95, 3.80] | 0.15 |
| Death To preservation time, hours [median (IQR)] | 9.60 (7.72, 13.00) | 10.3 (7.62, 14.17) | 0.33 | 10.8 [7.42, 14.6] | 11.1 [7.97, 15.2] | 0.21 |
| Recipient Factors | ||||||
| Recipient age, years [mean (SD)] | 70.3 (10.3) | 68.9 (10.22) | 0.14 | 72.13 (12.22) | 71.88 (11.78) | 0.83 |
| Recipient sex, male (%) | 36 (34.6) | 2375 (39.2) | 0.39 | 42 (43.3) | 5843 (42.5) | 0.95 |
| Recipient diagnosis (%) | 0.01 | 0.11 | ||||
| Post cataract surgery edema | 11 (10.1) | 655 (6.2) | 20 (19.2) | 3437 (18.7) | ||
| Ectasias/thinning | 0 (0.0) | 35 (0.3) | 0 (0.0) | 85 (0.5) | ||
| Endothelial dystrophies | 80 (73.4) | 7502 (71.6) | 39 (37.5) | 8621 (46.9) | ||
| Repeat corneal transplant | 10 (9.2) | 537 (5.1) | 17 (16.3) | 1709 (9.3) | ||
| Other/unknown | 8 (7.3) | 1752 (16.7) | 28 (26.9) | 4537 (24.7) | ||
*
Footnote: The data presented in this table is from the three eye banks from which both failure and non-failure data were available.
ECD = endothelial cell density
SD = standard deviation
IQR = interquartile range
DMEK = Descemet Membrane Endothelial Keratoplasty
DSAEK = Descemet Stripping Automated Endothelial Keratoplasty