Table 2.

Results of Generalized Linear Mixed Effects (GLME) regression models for early graft failures in DMEK and DSAEK.^*

Factor	DMEK			DSAEK
Factor	OR	95% CI	p-value	OR	95% CI	p-value
Donor Factors
Age (1 year unit change)	1.03	(1.00–1.05)	0.06	1.02	(1.00–1.05)	0.03
COD: cerebrovascular accident				0.41	(0.17–1.02)	0.05
COD: heart disease				0.50	(0.29–0.84)	<0.001
COD: respiratory disease				0.96	(0.48–1.95)	0.92
COD: trauma				0.59	(0.24–1.43)	0.24
COD: other				0.515	(0.22–1.21)	0.13
Initial ECD^**	0.96	(0.78–1.18)	0.68	1.21	(0.87–1.68)	0.27
Post-cut ECD^**				0.849	(0.61–1.18)	0.34
Death time to cooling (hours)				0.96	(0.86–1.08)	0.54
Recipient Factors
Age (1-year unit change)	1.02	(1.00,1.04)	0.10
Diagnosis: Ectasia/thinning ^§
Diagnosis: Endothelial dystrophies	0.63	(0.33,1.20)	0.156	0.539	(0.30,0.96)	0.04
Diagnosis: Repeat corneal transplant	1.08	(0.44,2.68)	0.861	1.44	(0.70,2.95)	0.318
Diagnosis: Other/unknown	0.47	(0.18,1.24)	0.128	1.17	(0.63,2.17)	0.614

Only factors achieving statistical significance of p<0.2 from the univariate analysis in Table 1 were included in the model (with factors not included in the models in gray). The reference group for Donor COD is a cause of death from cancer; the reference group for Recipient Diagnosis is a diagnosis of post-cataract surgery edema.

^**

ECD values were standardized for this model, where the unit increase is 1 standard deviation change of ECD.

^§

Excluded due to unstable and non-converging regression estimates obtained due to there being zero cases of recipient diagnosis of Ectasia or Thinning in the subset analysis group.

DMEK = Descemet Membrane Endothelial Keratoplasty

DSAEK = Descemet Stripping Automated Endothelial Keratoplasty

ECD = endothelial cell density

COD = Cause of Death

OR = odds ratio

CI = confidence interval

SE = standard error