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. 2022 Feb 5;28:16. doi: 10.1186/s10020-022-00445-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Expression of the 35 PRGs and the interactions among them. A Heatmap (blue: low expression level; orange: high expression level) of the PRGs between the nontumor (N, blue) and tumor samples (T, red). P values were shown as: **p < 0.01; ***p < 0.001. B PPI network showing the interactions of the PRGs (interaction score = 0.4). C The correlation network of the PRGs (red line: positive correlation; blue line: negative correlation. The depth of the colors reflects the strength of the relevance)