Fig. 4.

Linc00261 inhibits the growth of HCC cells in vivo. A Image of xenografts tissues after linc00261 overexpression in SMMC-7721 cells in vivo; the below histogram verified linc00261 expression in the xenograft tissues; the right pictures represent the HE staining of the xenograft tissues. B Linc00261 overexpression significant decrease the growth rates and tumor mass in SMMC-7721 cells in vivo. The (C, D) IHC analysis of EMT-related markers (C; E-cadherin, Vimentin, Slug, and ZEB1) and CSCs-related markers or transcription factors (D; CD44, CD133, OCT4, and SOX2) in xenograft tissues.* P < 0.05; ** P < 0.01; *** P < 0.001