TABLE 1.

Reported cases of PCL reactions presented as nodule or granuloma formations

Reference number	First author and year of publication	Age and gender	Location	Clinical presentation and type of reaction	Interval between injection and reaction	Management	Outcome
3	Moon et al./2017	36/male	Cheek, nasolabial folds, infraorbital	Granuloma	2 years	Doxycycline 100 mg twice daily for 1 month	Decreased lesions size
9	Skrzypek et al./2019	68/female	Marionette line	Granuloma	13 months	No treatment	No follow‐up
8	Chiang et al./2021	57/female	Tear trough	Granuloma	7 months	Excision	No recurrence
10	Philibert et al./2020	47/female	Cheeks and nasolabial folds	Eruptive granuloma	9 months	Methotrexate, 10 mg per week for 3 months, then 20 mg per week for 9 months	Complete regression
11	Ortiz‐Álvarez et al.	74/female	Nasolabial folds and over both zygomatic arches	Nodules which were then diagnosed with systemic sarcoidosis	3 months	Methotrexate (20 mg subcutaneous weekly) with prednisone (0.17 mg/kg/day)	Significant improvement