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. 2021 Sep 7;13(618):eabj3789. doi: 10.1126/scitranslmed.abj3789

Fig. 1. SARS-CoV-2 challenge with variant strain viruses drives clinical disease in hamsters.

Fig. 1.

Groups of Syrian golden hamsters were challenged intranasally with WA1/2020, B.1.1.7, or B.1.351 variant challenge virus in 100 μl of volume using the indicated dose of each challenge stock. After challenge, hamsters were monitored for 14 days for clinical signs of disease. (A to C) Average relative body weight of each group is displayed as means ± SEM for hamsters challenged with WA1/2020 (A), B.1.1.7 (B), or B.1.351 (C) variant strain challenge stock (n = 5 to 6 hamsters per group). (D) A comparison of the peak weight loss across variant virus strains and challenge doses is shown. Horizontal lines in (D) indicate the group means.