Table 1.
Marginal frequency table by diagnosis for the TexGen, UPMC, and EDRN cohorts.
| TexGen Cohort | UPMC Cohort | EDRN Cohort | Comparison among cohorts | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable | Level | Control | Cancer | P-value | Control | Cancer | P-Value | Control | Cancer | P-Value | P-value* |
| Diagnosis | Control | 30 (100%) | 0 (0%) | 25 (100%) | 0 (0%) | 18 (100%) | 0 (0%) | 0.2991 | |||
| Stage II PDAC | 0 (0%) | 58 (100%) | 0 (0%) | 34 (100%) | 0 (0%) | 44 (100%) | |||||
| Sex | Female | 29 (72%) | 11 (28%) | 0.260 | 12 (40%) | 18 (60%) | 0.795 | 9 (30%) | 21 (70%) | 1.0 | 0.8447 |
| Male | 28 (60%) | 19 (40%) | 13 (45%) | 16 (55%) | 9 (28%) | 23 (72%) | |||||
| Diabetes | No | 25 (36%) | 45 (64%) | 0.779 | 14 (38%) | 23 (62%) | 0.421 | 14 (33%) | 28 (67%) | 0.190 | 0.05857 |
| Yes | 5 (29%) | 12 (71%) | 11 (50%) | 11 (50%) | 2 (13%) | 13 (87%) | |||||
| Smoking | Current | 5 (100%) | 0 (0%) | 0.126 | 7 (47%) | 8 (53%) | 0.151 | - | - | - | 0.0023 |
| Former | 27 (71%) | 11 (29%) | 10 (59%) | 7 (41%) | - | - | - | ||||
| Never | 25 (57%) | 19 (43%) | 8 (30%) | 19 (70%) | - | - | - | ||||
| Location | Uncinate Process | NA | 0 (0%) | NA | 5 (15%) | NA | 4 (9%) | 0.0120 | |||
| Head | NA | 47 (81%) | NA | 19 (56%) | NA | 27 (61%) | |||||
| Neck | NA | 0 (0%) | NA | 1 (3%) | NA | 0 (0%) | |||||
| Body | NA | 4 (7%) | NA | 2 (6%) | NA | 2 (5%) | |||||
| Tail | NA | 2 (3%) | NA | 4 (12%) | NA | 4 (9%) | |||||
| Overlapping Lesion | NA | 3 (5%) | NA | 3 (9%) | NA | 0 (0%) | |||||
| Not specified | NA | 2 (3%) | NA | 0 (0%) | NA | 7 (16%) | |||||
| Controls | Healthy | 30 (100%) | NA | 0 (0%) | NA | 18 (100%) | NA | ||||
| Chronic pancreatitis (CP) | 0 (0%) | NA | 12 (48%) | NA | 0 (0%) | NA | |||||
| Abnormal image test (benign) | 0 (0%) | NA | 4 (16%) | NA | 0 (0%) | NA | |||||
| Benign stricture; biliary dilation | 0 (0%) | NA | 2 (8%) | NA | 0 (0%) | NA | |||||
| Acute pancreatitis | 0 (0%) | NA | 1 (4%) | NA | 0 (0%) | NA | |||||
| Autoimmune pancreatitis | 0 (0%) | NA | 1 (4%) | NA | 0 (0%) | NA | |||||
| Benign inflammatory changes | 0 (0%) | NA | 1 (4%) | NA | 0 (0%) | NA | |||||
| Common hepatic duct stricture | 0 (0%) | NA | 1 (4%) | NA | 0 (0%) | NA | |||||
| Intraductal papillary mucinous neoplasm (IPMN) | 0 (0%) | NA | 1 (4%) | NA | 0 (0%) | NA | |||||
| CP & IPMN | 0 (0%) | NA | 2 (8%) | NA | 0 (0%) | NA | |||||
| Age: median (Range) | 58.5 (22 – 80) | 64.0 (42 – 84) | 0.025 | 67.0 (43 – 84) | 64.0 (43 – 83) | 0.878 | 64.7 (52 – 85) | 71.2 (50 – 89) | 0.040 | <0.001 | |
*
Chi-square test was used to compare the diagnosis, sex, diabetes and smoking status marginal frequencies among cohorts. Kruskal-Wallis test was to compare the age difference among cohorts.