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. Author manuscript; available in PMC: 2022 Feb 6.
Published in final edited form as: Annu Rev Physiol. 2019 Sep 27;82:391–412. doi: 10.1146/annurev-physiol-021119-034602

Figure 1.

Figure 1

Schematic depiction of the core circadian clock for mammals. Clock genes are depicted as arrows, and their protein products are represented as ovals or circles. Yellow boxes depict E-boxes or ROR-responsive elements (RREs) that are bound by BMAL1/CLOCK or REV-ERB/ROR proteins, respectively. For simplicity, we have not depicted accessory proteins such as casein kinase 1δ/ε (CK1δ/ε) that serve to adjust periodicity and phase of the clock but are not central to rhythm generation (39). Note that there are additional molecular clock constituents (also not depicted) that are expressed selectively in the central nervous system, for example, NPAS2 (a functional homologue of CLOCK) and DEC1/2 (that provide additional negative feedback to BMAL1/CLOCK) (68, 142).